ISBT Barcelona 2024

• Date: Monday 24 June 2024, 13:00-17:00
• Location: Room 113
• Chairs and Moderators: Angelo D’Alessandro, Christian Erikstrup, Mike Busch
• Access: Open

Schedule

13:00 Michael P. Busch: Introduction  
13:10 Genetic and non-genetic factors regulate RBC hemolysis in the bag and upon transfusion    
    Angelo D’Alessandro: Omics-driven personalized Transfusion Medicine    
    James C. Zimring: Population studies in tractable murine systems    
    Travis Nemkov: Genetic and non-genetic factors regulate RBC metabolism    
    Nareg Roubinian: Lessons on post transfusion hemoglobin and bilirubin increments from the vein-to-vein database    
14:20 Break    
14:30 Large-scale donor and recipient studies    
    Christian Erikstrup: The Danish Blood Donor Study – even more data      
    Katja van den Hurk: Ferritin-guided iron supplementation in whole blood donors: optimal dosage, donor response, return and efficacy (FORTE) - a randomised controlled trial    
    Gustaf Edgren: Using routine health care data to search for unknown transfusion-transmitted disease: a nationwide, agnostic retrospective cohort study    
    Emanuele Di’Angelantonio: STRIDES - improving donor experiences     
    Simon Stanworth: Towards a Pan-European Transfusion Research infrAstructure (PETRA) 
    Sheila O’Brien: Blood donor research: New directions at Canadian Blood Services
16:20 Break    
16:30-17:00 Angelo D’Alessandro and Christian Erikstrup: Establishing the Big Data Working Party    

Registration form 

• Date: Monday 24 June 2024, 09:00-12:00
• Location: Room 113
• Chairs: Karina Yazdanbakhsh, Rick Kapur
• Access: Open - Attendees with relevant scientific background are welcome to join this meeting.

There is a proposal for a new ISBT Basic Transfusion Biology Working Party. The purpose of this new group is to promote research in basic biology of transfusion science, raise awareness of advancements in novel and emerging methodologies relevant to transfusion biology, and facilitate translation of the scientific discoveries in basic science of transfusion biology through educational initiatives. 

Scope

To bring together ISBT members in the field of basic transfusion medicine research, who work with the ISBT academy and contribute to ISBT education, training initiatives and webinars. The Working Party also organizes sessions and workshops on Transfusion Biology at ISBT congresses.
To serve as a knowledge base for ISBT members, providing information and educational resources on the ISBT website and highlight the importance of investigations aimed at obtaining novel mechanistic insights and propagate recent discoveries in basic biology and their translation potential. This will include areas such as: 
    -novel blood component and cell therapy products, mechanisms of response to non-infectious and infectious transfusions, pathophysiology of hematologic disorders and adverse events in the context of transfusions.
     -advancements in tools and technological advances including novel animal models of transfusion and advanced technologies for in vitro human and animal cellular assays and biochemical assays related to basic biology, including methodologies that would benefit low-middle HDI countries, and facilitate knowledge transfer.

The Basic Transfusion Biology Working Party establishes collaborations with other ISBT working parties and with non-ISBT bodies and societies with similar aims in line with the ISBT strategy. When needed, the Working Party establishes subgroups to complete key projects based on priorities agreed by the working party members. 

Schedule

9:00-9:35 Setting the scene
Why a WP on Transfusion Biology? - Karina Yazdanbakhsh
How could it work? - Rick Kapur
Proposed operational logistics and membership/recruitment - John Semple

9:45 -11:00  Examples of Prioritized Studies (15 min. each)
Pathophysiology of Pulmonary Transfusion Reactions (eg TRALI/TACO) - Rick Kapur
Mechanisms of Immune Responses to RBC and Platelets (e.g. transfusions, pregnancies) - Karina Yazdanbakhsh 
Molecular Pathways for Novel Blood Components using iPSCs - Emile van den Akker
Translation of Platelet autoimmunity from Serology to Functionality - John Semple
Tailored CARs for Novel Indications (e.g. autoimmunity, asthma) - Don Siegel (by Zoom).
.

11:10-12:00 Discussion (Audience Participation)
What would you like to be the focus of a ISBT WP on Transfusion Biology?
What relevant in vitro and in vivo models would you like explore for your specific research questions?
Which specific collaborations would you deem useful with a Transfusion Biology WP? 

• Date: Sunday June 23 2024, 10:30-12:30
• Location: Room 128
• Chair and Vice Chair: Denese Marks and Susanne Marschner
• Access: WP Members only

• Date: Monday June 24 2024, 9:30-11:30
• Location: Room 118
• Chair: Rada Grubovic Rastvorceva
• Access: WP members only

Meeting schedule

I. Opening
II. Welcome and self-introduction
III. Apologies
IV. Confirmation of Agenda
V. Confirmation of minutes of WP BSM Hybrid Meeting at ISBT Congress 2023 at Gothenburg, Sweeden
VI. Matters arising from previous meeting
VII. Ongoing projects

• Update on survey on Blood Supply Management during the COVID-19 pandemic – Merlyn Sayers 
• Remote Site Blood Management project – Graham Murdoch
• Magnitude and associated factors of unmet needs of blood products among patients in low- and middle-income countries Survey – Amita Rnair
• Red cell usage trends in low- and middle-income countries – Neil Beckman 
• BSM WP Newsletter and Forum post – Neil Beckman 
• Supply Chain Challenges – Impact on Transfusion Medicine Services Survey – Suzan Nahirniak

VIII. Other activities

• Call for BSM WP Webinars for 2024/2025
• Call for BSM WP Newsletter and Forum posts
• Guideline on good practices in BSM

IX. Appointment of Educational Officer
X. Recruitment of new members for the BSM WP
XI. Any other business (AOB)
XII. Next meeting/ Closure and farewell

• Date: Sunday 23 June 2024, 13:30-15:30
• Location: Room 128
• Chair: Reinhard Henschler
• Access: WP members only

• Date: Sunday June 23 2024, 16:00-17:30
• Location: Room 130
• Chair: Frederik Banch Clausen
• Access: Open

• Date: Monday 24 June 2024, 11:30-14:00
• Location: Room 118
• Chair: Arwa Al-Riyami
• Access: WP members only

• Date: Sunday 23 June 2024, 12:30-16:30
• Location: Room 127
• Chair: Rachel Thorpe
• Access: WP members only

• Date: Sunday 23 June 2024, 16:00-18:00
• Location: Room 129
• Chair: Jay Epstein
• Access: Open

• Date: Monday 24 June 2024, 15:00-16:00
• Location: Room 118
• Chair: Behnaz Bayat
• Access: WP members only

• Date: Sunday 23 June 2024, 10:30-12:30
• Location: Room 127
• Chair: Mary Townsend
• Access: WP members only

• Date: Sunday 23 June 2024, 16:00-18:00
• Location: Room 131
• Chair and Vice Chair: Thierry Peyrard and Nicole Thornton
• Access: WP members only

• Date: Monday 24 June 2024, 14:00-17:00
• Location: Room 119
• Chair and Vice Chair: Suzanne Butch and Shankar Goudar
• Access: WP members only

• Date: Sunday 23 June 2024, 10:30-12:30
• Location: Room 129
• Chair: Brin Curtis
• Access: WP members only

• Date: Monday 24 June 2024, 10:30-12:30
• Location: Room 119
• Chair and Vice Chair: Nigar Ertuğrul Örüç, Christian Seidl
• Access: WP members only

• Date: Sunday 23 June 2024, 09:30-12:30
• Location: Room 131
• Chair and Vice Chair: Vered Yahalom, Thierry Peyrard
• Access: WP members only

• Date: Sunday 23 June 2024, 13:30-15:30
• Location: Room 131
• Co-Chairs: Christoph Gassner, Catherine Hyland
• Access: WP members only

• Date: Sunday 23 June 2024, 09:00-13:30 (Global TTID WP), subgroups from 13:30-17:00
• Location: Room 120-121, 122-123
• Chair: Brian Custer
• Access: WP members only

Time (local time)    Presenter    Topic:  
09:30 – 09:45    Brian Custer    Introductions, Update on WP, and Business Items

09:45 – 10:10    Susan Galel    Update on transfusion-transmitted malaria and new tools to identify infections - 20-minute talk plus 5 minutes for discussion

10:10 – 10:25   Silvia Sauleda    Improving NAT screening strategies in real life: Simultaneous ID-NAT detection of HCV, HIV-1, HIV-2, HBV and HEV in blood donations - 20-minute talk plus 5 minutes for discussion

10:25 – 11:00   Oleg Krut            Endotoxin content and pyrogenicity of bacterially contaminated platelet concentrates - 20-minute talk plus 5 minutes for discussion

11:00 – 11:20        Coffee/Tea Break 

11:20 – 11:50    Mike Busch    Donor screening and contributions to public health and understanding of disease: Focus on respiratory viruses - 25-minute talk plus 5 minutes for discussion

11:50 – 12:55    Subgroup Updates    
Subgroup Activities in the last year (~10-minute presentation followed by 5-minute discussion for each subgroup)
•    Parasites (Steve Drews)
•    Surveillance Risk Assessment and Policy (Sheila O’Brien)
•    Virology (Daniel Candotti)
•    Bacteria (Carl McDonald)

13:00 – 13:30             Lunch

After lunch: Concurrent Subgroup Sessions from 13:30 - 90 minutes each for sessions 1 and 2

Concurrent Session 1, Bacteria: 
Time (local time): 13:30 – 15:00 CEST
Room 122-123
Meeting schedule    

Introduction by Sandra Ramirez/Carl McDonald subgroup coordinators
1. Pierre Tiberghien (SFE, France)
2. Anthea Cheng (Australian Red Cross, Australia)
3. Jennifer Bearne (NHSBT, UK)
4. Sandra Ramirez (Canadian Blood Services, Canada)

Concurrent Session 1, Virology:  
Time: 13:30 – 15:00 CEST    
Room 120-121     
Meeting schedule    

•    Daniel Candotti / Helen Faddy (online)
    
15:00-15:00 Coffee/Tea break 
 
Concurrent Session 2, Parasites
Time: 15:30-17:00 CEST
Room 122-123
Meeting schedule 
1. Introduction 5 minutes (15:30-15:35)
2. Grifols malaria study- background, design, and logistical considerations (Josephine Mitchel, South African National Blood Service), 20 minutes, 5 minutes discussion (15:35-16:00)  
2. MERIT trial (Evan Bloch), 20 minutes, 5 minutes discussion (16:00-16:15)  
3. ISBT parasitology subgroup project pitch session, 30 minutes (16:15-16:45)    
- Steve and Evan will pitch some project ideas to group
- Other members have been asked to bring ideas for the pitch session   
4. Project(s) identified and next steps actioned, 10 minutes (16:45-16:55)
5. Wrap-up, 5 minutes (16:55-17:00)

Concurrent Session 2, SRAP:
Time: 15:30-17:00 CEST
Room 120-121
Meeting schedule:    

1. Welcome – Sheila O’Brien
2. Chagas’ disease risk mitigation approaches: Survey results – Antoine Lewin
3. Anti-HBc testing : Implications for ethnic diversity – Heli Harvala
4. Molecular Surveillance : New insights and current directions – Daniel Candotti
5. PrEP and transfusion safety – Brian Custer

18:00 – 19:00 Working Party Reception (for all Working Parties)
Location: Patio