Welcome to the quarterly Transfusion Evidence Round-Up. This is a collaboration between the International Society of Blood Transfusion (ISBT) and the Transfusion Evidence Library (TEL).  We aim to highlight high quality evidence randomised controlled trials and systematic reviews about an internationally relevant subject in the field of Transfusion Medicine.  All references are drawn from the Transfusion Evidence Library and, where relevant, Stem Cell Evidence.

This newsletter is sent to ISBT members and TEL subscribers, so if you are a subscriber to both mailing lists and receive it twice please bear with us until we can resolve this. 

The Transfusion Evidence Library is produced by the Systematic Review Initiative (SRI) and funded by the four UK blood services. It is available free at the point of access providing a comprehensive and up-to-date database of high quality evidence in Transfusion Medicine.


Top 10 articles

Ten articles are highlighted to bring attention to this year’s International Thalassaemia Day.

These articles have been identified from the Transfusion Evidence Library and selected by ISBT members: Dr. Sheetal MalhotraDr. Laura Infanti, and Dr. Catarina Jacinto Correia.

Top article

Impact of Red Blood Cell Antigen Matching on Alloimmunization and Transfusion Complications in Patients with Sickle Cell Disease: A Systematic Review. Fasano, R.M., et al. (2018). Transfusion Medicine Reviews.

PICO Summary


Selected articles

The effect of iron chelation therapy on overall survival in sickle cell disease and beta-thalassemia: a systematic review.
Ballas, S.K, et al. (2018). American Journal of Hematology.

Systematic literature review of the burden of disease and treatment for transfusion-dependent beta-thalassemia.
Betts, M., et al. (2019). Clinical Therapeutics.

A Phase 3 Trial of Luspatercept in Patients with Transfusion-Dependent beta-Thalassemia.
Cappellini, M.D., et al. (2020). New England Journal of Medicine.

Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews.
Fortin, P.M., Hopewell, S., and Estcourt, L.J., (2018). The Cochrane Database of Systematic Reviews. 

Red blood cell alloimmunisation in transfusion-dependent thalassaemia: a systematic review.
Franchini, M., et al. (2019). Blood Transfusion.

Evidence-based interventions implemented in low-and middle-income countries for sickle cell disease management: A systematic review of randomized controlled trials.
Gyamfi, J., et al. (2021). PloS One

COVID-19 and Hemoglobinopathies: A Systematic Review of Clinical Presentations, Investigations, and Outcomes.
Lee, J.X., et al. (2021). Frontiers in Medicine.

Gene therapy for sickle cell disease.
Olowoyeye, A., and Okwundu, C.I., (2020). The Cochrane Database of Systematic Reviews.

Interventions for chronic kidney disease in people with sickle cell disease.
Roy, N.B, et al. (2017). The Cochrane Database of Systematic Reviews.

Editorial Board

Sheetal Malhotra

Sheetal Malhotra

Assistant Professor , Department of Transfusion Medicine, PGIMER, Chandigarh, India

Laura Infanti

Laura Infanti

Blood Donation Centre, Swiss Red Cross, Basel, Switzerland

Catarina Jacinto Correia

Catarina Jacinto Correia

Doctor in Immunohemotherapy, Hospital de Santa Maria, Portugal


Systematic Research Initiative

Systematic Research Initiative

The Systematic Review Initiative (SRI) is a clinical research group established in 2001 by NHS Blood and Transplant (NHSBT) and funded by the UK Blood Services. The primary objective of the SRI is to “develop the evidence base for the practice of transfusion medicine”, by undertaking systematic reviews and other evidence-based medicine research projects in the transfusion field. @sritransfusion

Transfusion Evidence Library

Transfusion Evidence Library

The Transfusion Evidence Library is a database of systematic reviews and randomised controlled trials relevant to transfusion medicine. It is fully searchable, updated monthly and aims to be a key resource for medical practitioners, policy makers and researchers both in the UK and around the world. A monthly email: The Transfusion Evidence Alert with the latest top 10 records is sent to subscribers. The library is produced by the Systematic Review Initiative and funded by the UK Blood Services.
Stem Cell Evidence

Stem Cell Evidence

Stem Cell Evidence is a comprehensive collection of high quality research relevant to haematopoietic stem cell transplantation, updated monthly. The most important articles in the field are highlighted in the Stem Cell Evidence Alert which is a newsletter emailed to subscribers. Stem Cell Evidence aims to be a key resource worldwide for medical practitioners, clinical researchers and policy makers. It is also intended to be of value to those planning new clinical trials in the field. It is produced by the Systematic Review Initiative and funded by the UK Blood Services and Oxford Biomedical Research Centre.