Transfusion Evidence Round-Up "World Heart Day"

Live Journal Club

On October 19, 2023, the TER coordinators Allison Mo, Susan Brunskill and Catherine Kimber held a Live Journal Club where they invited the reviewers to discuss selected papers from the Round-Up.

Watch the Live Journal Club Recording


Welcome to the quarterly Transfusion Evidence Round-Up

This is a collaboration between the International Society of Blood Transfusion (ISBT) and the Transfusion Evidence Library (TEL).  We aim to highlight high quality evidence randomised controlled trials and systematic reviews about an internationally relevant subject in the field of Transfusion Medicine.  All references are drawn from the Transfusion Evidence Library and, where relevant, Stem Cell Evidence.

This Transfusion Evidence Round-Up is sent to ISBT members and TEL subscribers, so if you are a subscriber to both mailing lists and receive it twice please bear with us until we can resolve this.
The Transfusion Evidence Library is produced by the Systematic Review Initiative (SRI) and funded by the four UK blood services. It is available free at the point of access providing a comprehensive and up-to-date database of high quality evidence in Transfusion Medicine.

Top 10 articles

Like always in the Round-Ups, 10 articles were selected from the Transfusion Evidence Library by 3 reviewers: Luis Larrea, Rizwan Javed and Meri Shorova​​​​​.

Top article 2023 World Heart Day

Perioperative transfusion and long-term mortality after cardiac surgery: a meta-analysis Woldendorp K, et al. (2023). General Thoracic and Cardiovascular Surgery

PICO Summary


Selected articles

hand pointing to the right.png

These articles were discussed during the Live Journal Club.

Impact of cardiopulmonary bypass duration on efficacy of fibrinogen replacement with cryoprecipitate compared with fibrinogen concentrate: a post hoc analysis of the Fibrinogen Replenishment in Surgery (FIBRES) randomised controlled trial.
Bartoszko, J., et al. (2022). British Journal of Anaesthesia. 

Autologous red blood cell transfusion does not result in a more profound increase in pulmonary capillary wedge pressure compared to saline in critically ill patients: A randomized crossover trial.
Bosboom, J.J., et al. (2022). Vox Sanguinis. 

hand pointing to the right.png

Meta-analysis of reversal agents for severe bleeding associated with direct oral anticoagulants.
Gómez-Outes, A., et al. (2021). Journal of the American College of Cardiology. 

Prothrombin complex concentrate in cardiac surgery for the treatment of coagulopathic bleeding.
Hayes, K., Fernando, M.C., and Jordan, V., (2022). The Cochrane Database of Systematic Reviews.

Health-related quality of life after restrictive versus liberal RBC transfusion for cardiac surgery: Sub-study from a randomized clinical trial.
Hu, R.T., et al. (2022). Transfusion. 

Modified ultrafiltration reduces postoperative blood loss and transfusions in adult cardiac surgery: a meta-analysis of randomized controlled trials.
Low, Z.K., et al. (2021).  Interactive Cardiovascular and Thoracic Surgery. 

A pilot randomized clinical trial of cryopreserved versus liquid-stored platelet transfusion for bleeding in cardiac surgery: The cryopreserved versus liquid platelet-New Zealand pilot trial.
McGuinness, S., et al. (2021). Vox Sanguinis.

Prothrombin complex concentrate vs plasma for post-cardiopulmonary bypass coagulopathy and bleeding: a randomized clinical trial.
Smith, M.M., et al. (2022). JAMA Surgery. 

Restrictive vs. liberal red blood cell transfusion strategy in patients with acute myocardial infarction and anemia: a systematic review and meta-analysis.
Zhang, Y., et al. (2021). Frontiers in Cardiovascular Medicine.

hand pointing to the right.png

Perioperative transfusion and long-term mortality after cardiac surgery: a meta-analysis.
Woldendorp, K., et al. (2023). General Thoracic and Cardiovascular Surgery. 


Editorial Board

Luis Larrea

Luis Larrea

Head of the Processing Department, Valencian Transfusion Center, Spain

Rizwan Javed

Rizwan Javed

Consultant in Apheresis and Cellular therapy, TATA Medical Center, Kolkata, India


Systematic Research Initiative

Systematic Research Initiative

The Systematic Review Initiative (SRI) is a clinical research group established in 2001 by NHS Blood and Transplant (NHSBT) and funded by the UK Blood Services. The primary objective of the SRI is to “develop the evidence base for the practice of transfusion medicine”, by undertaking systematic reviews and other evidence-based medicine research projects in the transfusion field. @sritransfusion

Transfusion Evidence Library

Transfusion Evidence Library

The Transfusion Evidence Library is a database of systematic reviews and randomised controlled trials relevant to transfusion medicine. It is fully searchable, updated monthly and aims to be a key resource for medical practitioners, policy makers and researchers both in the UK and around the world. A monthly email: The Transfusion Evidence Alert with the latest top 10 records is sent to subscribers. The library is produced by the Systematic Review Initiative and funded by the UK Blood Services.
Stem Cell Evidence

Stem Cell Evidence

Stem Cell Evidence is a comprehensive collection of high quality research relevant to haematopoietic stem cell transplantation, updated monthly. The most important articles in the field are highlighted in the Stem Cell Evidence Alert which is a newsletter emailed to subscribers. Stem Cell Evidence aims to be a key resource worldwide for medical practitioners, clinical researchers and policy makers. It is also intended to be of value to those planning new clinical trials in the field. It is produced by the Systematic Review Initiative and funded by the UK Blood Services and Oxford Biomedical Research Centre.