International Clinical Trials Day 2025
Talking Transfusion Podcast
Tune into the third episode of the Talking Transfusion Podcast!
Introduction
Welcome to the quarterly Transfusion Evidence Round-Up.
This is a collaboration between the International Society of Blood Transfusion (ISBT) and the Transfusion Evidence Library (TEL). We aim to highlight high quality evidence randomised controlled trials and systematic reviews about an internationally relevant subject in the field of Transfusion Medicine. All references are drawn from the Transfusion Evidence Library and, where relevant, Stem Cell Evidence.
This Transfusion Evidence Round-Up is sent to ISBT members and TEL subscribers, so if you are a subscriber to both mailing lists and receive it twice please bear with us until we can resolve this.
The Transfusion Evidence Library is produced by the Systematic Review Initiative (SRI) and funded by the four UK blood services. It is available free at the point of access providing a comprehensive and up-to-date database of high quality evidence in Transfusion Medicine.
Top 10 articles
The following 10 articles were selected from the Transfusion Evidence Library by 3 reviewers: Abhishekh B, Kamini Khillan and Catriona Parker.
Top article
Topical Versus Intravenous Tranexamic Acid in Patients Undergoing Cardiac Surgery: The DEPOSITION Randomized Controlled Trial
Selected articles
Delayed cold-stored vs. room temperature stored platelet transfusions in bleeding adult cardiac surgery patients-a randomized multicentre pilot study (PLTS-1) Bartoszko, J., et al. (2024). Pilot and Feasibility Studies.
Hypovolaemic phlebotomy in patients undergoing hepatic resection at higher risk of blood loss (PRICE-2): a randomised controlled trial. Martel, G., et al. (2025). The Lancet Gastroenterology & Hepatology.
Safety and efficacy of tranexamic acid in general surgery. Park, L.J., et al. (2025). JAMA Surgery.
A randomised controlled trial assessing the effect of tranexamic acid on post-operative blood transfusions in patient with intra-capsular hip fractures treated with hemi- or total hip arthroplasty. Khatib, Y., et al. (2024). Archives of Orthopaedic and Trauma Surgery.
Tranexamic acid during radical cystectomy: a randomized clinical trial. Breau, R.H., et al. (2024). JAMA Surgery.
Evaluating the safety and efficacy of a novel polysaccharide hemostatic system during surgery: a multicenter multispecialty prospective randomized controlled trial. House, M.G., et al. (2024). Surgery Open Science.
Hospital policy of tranexamic acid to reduce transfusion in major non-cardiac surgery (TRACTION): protocol for a phase IV randomised controlled trial. Houston, B.L., et al. (2024). BMJ Open.
The effect of perioperative sequential application of multiple doses of tranexamic acid on postoperative blood loss after PLIF: a prospective randomized controlled trial. Dong, W., et al. (2024). International Journey of Surgery.
Tranexamic acid in patients undergoing liver resection: the HeLiX randomized clinical trial. Karanicolas, P.J., et al. (2024). JAMA.
Editorial Board
Catriona Parker
Biography
Dr Parker is an Early Career Research Fellow at Monash University in the Transfusion Research Unit and holds research interests in patient experience and outcomes, utilising qualitative and mixed-methods expertise to provide novel insights.
Dr Parker’s PhD, in the field of acute myeloid leukaemia survivorship care examined financial burden using a mixed methods study design. Dr Parker has had a diverse career before academia in diagnostic laboratories, before moving into clinical trials and policy and advocacy with roles in both private and not-for-profit organisations. Dr Parker has led a number of policy initiatives and research to improve cancer care and the experiences of patients and is passionate about embedding and increasing the profile of the patient lived experience in research and clinical trials.
Dr Parker is actively engaged with the oncology and haematology community through membership and committees with the Australasian Lymphoma and Leukaemia Group (Supportive Care Working Group) the Multinational Association of Supportive Cancer in Care (MASCC) (Supportive Care and Palliative Care committees) and the Australian and New Zealand Society of Blood Transfusion (ANZSBT).
Abhishekh B
Dr Abhishekh B is currently an Additional Professor and heading the Department of Transfusion Medicine at Jawaharlal Institute of Postgraduate Medical Education and Research(JIPMER), Puducherry. He has been a recipient of various awards, namely the H D Shourie Award from ISBTI Young Scientist Award from ISTM. He is the Co-chair of the AATM working party on Cellular therapy. He is also part of the ISBT working party of clinical transfusion and the Special Interest group on donor management.
He has authored 2 books: Manual of Immunohematology for Transfusion Residents (MITR) and an exam primer for MD transfusion medicine. He has also been the editor of a book on “Transfusion Reactions.” He has authored more than 100 research articles in multiple international and national journals and chapters in various textbooks.
Systematic Research Initiative
The Systematic Review Initiative (SRI) is a clinical research group established in 2001 by NHS Blood and Transplant (NHSBT) and funded by the UK Blood Services. The primary objective of the SRI is to “develop the evidence base for the practice of transfusion medicine”, by undertaking systematic reviews and other evidence-based medicine research projects in the transfusion field. @sritransfusion
- Twitter:
- @sritransfusion
Transfusion Evidence Library
- Twitter:
- @transfusionlib
Stem Cell Evidence
Stem Cell Evidence is a comprehensive collection of high quality research relevant to haematopoietic stem cell transplantation, updated monthly. The most important articles in the field are highlighted in the Stem Cell Evidence Alert which is a newsletter emailed to subscribers. Stem Cell Evidence aims to be a key resource worldwide for medical practitioners, clinical researchers and policy makers. It is also intended to be of value to those planning new clinical trials in the field. It is produced by the Systematic Review Initiative and funded by the UK Blood Services and Oxford Biomedical Research Centre.
- Twitter:
- @evidencestemc