ISBT Webinar: Non-DEHP blood bag system for red blood cell storage: in vitro quality, practical performance, and clinical efficacy

Aim of the webinar:

Learn from recent experience as our industry navigates the transition to non-DEHP-PVC blood bag systems. Covering red blood cell in vitro quality in non-DEHP bags, describing practical experience with use of non-DEHP blood bag systems, and examining clinical efficacy and hemovigilance data, this webinar will provide attendees with practical insights to guide their transition plans.

Highlights

Improve understanding of how the RBC membrane behaves in the absence of DEHP, including when subjected to cumulative stresses such as irradiation.

Explore how in vitro findings translate to in vivo outcomes and clinical evaluation.

Level of education required:

3 - intermediate (practical application)

What prior knowledge is required?

The attendees are encouraged to read the below.

Stephenson T, Howell A, Olafson C, Sumian C, Reichenberg S, Brebant Q, McTaggart K, Walsh GM. In vitro quality of whole blood-derived red cell concentrates collected, processed and stored in a blood bag set plasticized with di (2-ethylhexyl) terephthalate . Vox Sang. 2025 Aug 6. doi: 10.1111/vox.70087. Epub ahead of print. PMID: 40769770.

Vermeulen C, den Besten G, van den Bos AG, Go M, Gouwerok E, Vlaar R, Schipperus MR, Spelmink SE, Janssen M, Lagerberg JW, de Korte D, Klei TRL. Clinical and in vitro evaluation of red blood cells collected and stored in a non-DEHP plasticized bag system. Vox Sang. 2022 Oct;117(10):1163-1170. doi: 10.1111/vox.13344. Epub 2022 Sep 14. PMID: 36102116.

Vermeulen C, van Geloven N, Mertens B, Spelmink SE, Schipperus MR, Janssen MP, Kerkhoffs JH, den Besten G, van den Bos AG, Körver-Keularts IMLW, van de Kerkhof D, Klinkspoor HJH, De Vooght KMK, van Gammeren AJ, Russcher H, Heijnen JWM, de Korte D, van der Meer PF, Klei TRL. Clinical evaluation of red cell concentrates in non-DEHP plasticized containers compared with standard DEHP plasticized containers: A quasi-randomized observational multicentre study . Vox Sang. 2025 Mar 24. doi: 10.1111/vox.70019. Epub ahead of print. PMID: 40129135.