Sickle Cell and Transfusion: Bridging the Gap in Patient Care

Aim of the webinar: 

• Understand transfusion difficulties in sickle cell disease and implement appropriate analyses.
• Prevent, diagnose and treat post-transfusion hemolysis in patients with sickle cell disease

Level of education required:  

Intermediate (practical application), Advanced (applied theory), Expert (recognized authority)

What knowledge is required? 

• Basic immuno hematology, basic red blood cell physiology and pathophysiology
• Knowledge of basic transfusion protocols

We'd recommend you to read the below publications:

• Thein SL, Pirenne F, Fasano RM, Habibi A, Bartolucci P, Chonat S, Hendrickson JE, Stowell SR. Hemolytic transfusion reactions in sickle cell disease: underappreciated and potentially fatal. Haematologica. 2020 Mar;105(3):539-544. doi: 10.3324/haematol.2019.224709. Epub 2020 Feb 6. PMID: 32029505; PMCID: PMC7049330.
• Chou ST, Alsawas M, Fasano RM, Field JJ, Hendrickson JE, Howard J, Kameka M, Kwiatkowski JL, Pirenne F, Shi PA, Stowell SR, Thein SL, Westhoff CM, Wong TE, Akl EA. American Society of Hematology 2020 guidelines for sickle cell disease: transfusion support. Blood Adv. 2020 Jan 28;4(2):327-355. doi: 10.1182/bloodadvances.2019001143. PMID: 31985807; PMCID: PMC6988392.
• Pirenne F, Yazdanbakhsh K. How I safely transfuse patients with sickle-cell disease and manage delayed hemolytic transfusion reactions. Blood. 2018 Jun 21;131(25):2773-2781. doi: 10.1182/blood-2018-02-785964. Epub 2018 May 3. PMID: 29724898; PMCID: PMC6014354.
• Chou ST, Hendrickson JE. How I Treat Challenging Transfusion Cases in Sickle Cell Disease. Blood. 2024 May 10:blood.2023023648. doi: 10.1182/blood.2023023648. Epub ahead of print. PMID: 38728382.

Target audience

Scientists, blood bankers, transfusion practitioners, practitioners in immuno hematology laboratory