Transfusion Transmitted Infectious Diseases
Following blood transfusion, there is a risk of transfusion-transmitted infectious diseases (TTID), despite current advanced screening technologies. Infectious agents involved are very diverse and include hepatitis B (HBV), hepatitis C (HCV), human immunodeficiency (HIV-1/2), human T-cell lymphotropic (HTLV-I/II), Cytomegalo- (CMV), Parvo- B19, West Nile (WNV) and Dengue viruses. Trypanosomiasis, malaria, and Transmissible Spongiform Encephalopathy (TSE) also belong to TTID. TTID can be reduced by donor exclusion, screening for serological infection markers or nucleic acid testing (NAT) by viral gene amplification. Despite this, blood-borne infectious agents are transmitted through transfusion of infected blood donated by apparently healthy and asymptomatic blood donors.
The Working Party on Transfusion Transmitted Infectious Disease (WP-TTID) focuses its activities on understanding infectious diseases in transfusion, including conducting research and assessments that contribute to increasing the safety of the blood supply across jurisdictions. We accomplish our work by bringing together international experts to: 1) gather, analyse and review relevant data; 2) develop and coordinate international studies; 3) publish scientific reports; and 4) to actively contribute to policy discussions, including advocacy for blood safety interventions in all regions of the world based on differences in epidemiology and resources. The WP-TTID members are scientific experts, regulators, company representatives and other participants from leading institutions in the fields of blood safety and infectious diseases
Our members participate in the following subgroups:
4) Surveillance, Risk Assessment & Policy (SRAP), including surveillance for Prions/Transmissible spongiform encephalopathy (TSE)
Our Chairperson is Brian Custer.
We participate in subgroups and attend 1-2 day WP meetings linked to ISBT Congresses. Our subgroups develop and execute various surveys and laboratory experiments, analyse data with the intention to publish. Our subgroups discuss issues by conference call and in person. We sponsor Travel Awards and are launching a mentoring and training program for early/mid-career investigators, particularly from resource-limited countries.
Applicants for membership must have a documented interest in TTID and preferably be involved in TTID surveillance or research. Equal representation of all world regions is a priority; we currently have over 120 members from 32 different countries.
Employees from pharmaceutical companies are only able to join as Corporate Sponsors.
Interested in joining the TTID WP? Please email the ISBT Office or our Chairperson.
Vice Chair: Sheila O’Brian, Canada
Corporate Member Representative: Marion Lanteri, USA
Individual Member Representatives: Marion Vermeulen, South Africa and Michael Schmidt, Germany
Some of the content is only accessible for ISBT-members. To join us, click here.
- Bacterial safety of blood components–a congress review of the ISBT transfusion‐transmitted infectious diseases working party, bacterial subgroupISBT Science Series, 18 March 2019
- A pilot serosurvey of Babesia microti in Chinese blood donors.Vox Sang. 2018 Mar 26. doi: 10.1111/vox.12648
- Enlargement of the WHO international repository for platelet transfusion‐relevant bacteria reference strainsVox Sang 2017 Sept, 112, 713–722, doi.org/10.1111/vox.12548
- Development of a web‐based application and multicountry analysis framework for assessing interdicted infections and cost‐utility of screening donated blood for HIV, HCV and HBVVox Sang 2017 June, 112, 526–534, doi.org/10.1111/vox.12538
- Survey for bacterial testing of platelet components in Latin AmericaISBT Science Series, 2017 May 17
- Zika virus: a new challenge for blood transfusionThe Lancet, 2016
- Comparison of seven hepatitis B virus (HBV) nucleic acid testing (NAT) assays in selected samples with discrepant HBV marker results from United States blood donors. Transfusion 2014 Oct;54(10):2485-95. doi.org/10.1111/trf.12653
- The international experience of bacterial screen testing of platelet components with an automated microbial detection system: a need for consensus testing and reporting guidelines Transfus Med Rev. 2014 Apr;28(2):61-71.
- Establishment of the first international repository for transfusion-relevant bacteria reference strains: ISBT working party transfusion-transmitted infectious diseases (WP-TTID), subgroup on bacteriaVox Sang. 2012 Jan;102(1):22-31. doi: 10.1111/j.1423-0410.2011.01510.x.
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Vitalant Research Institute
San Francisco, USA